A recent prospective randomized test of the effects of plasma exchange (PE) combined with immune globulin (IG) therapy on consciousness, immune function and prognosis in patients with myasthenia gravis crisis (MGC) has found it not only safely and effectively enhances the consciousness and immune function of patients, but also effectively promotes the prognosis.
In the study, 60 patients with MGC were treated from February 2019 to April 2021 with either PE only or combined IG plus PE. The efficacy, clinical score, state of consciousness, immune function, acetylcholine receptor antibody (AChR-Ab), lymphocyte (LYM), albumin (ALB) levels and the incidence of adverse reactions were compared. Findings showed the improvement rate was 100.005 percent in the PE plus IG group and 83.33 percent in the PE group; after treatment, the clinical score of the PE plus IG group was lower than that of the PE group, and the clinical relative score of the PE plus IG group was higher than that of the PE group; the number of conscious people in the PE plus IG group was more than that in the PE group; immunoglobulin A (IgA), IgM and IgG in the PE plus IG group were higher than those in the PE group; the levels of AChR-Ab and ALB in the PE plus IG group were higher than those in the PE group, while the level of LYM in the PE plus IG group was lower than that in the PE group; and the incidence of skin system, gastrointestinal system, nervous system and systemic damage in the PE plus IG group was lower than that in the PE group.
Reference
- Peng, X, Xie, X-B, Tan, H, et al. Effects of Plasma Exchange Combined with Immunoglobulin Therapy on Consciousness, Immune Function and Prognosis in Patients with Myasthenia Gravis Crisis: A Prospective Randomized Test. Computational and Mathematical Methods in Medicine, Vol. 2022, Article ID 7796833. Accessed at onlinelibrary.wiley.com/doi/10.1155/2022/7796833.
