Diagnoses & Conditions

Selective Antibody Deficiency (SAD)

Understanding Selective Antibody Deficiency (SAD)

Selective Antibody Deficiency (SAD) is characterized by normal or near normal immunoglobulin levels and an impaired antibody response. An inability to produce antibodies may result in the patient being susceptible to certain kinds of infections, but not others.

Symptoms of Selective Antibody Deficiency (SAD)

Patients with SAD may have symptoms which include recurrent ear infections, sinusitis, bronchitis and pneumonia. Infections in SAD patients are not as severe as patients who have combined deficiencies of immunoglobulin types G, A and M (IgG, IgA and IgM) such as agammaglobulinemia or Common Variable Immune Deficiency.

Diagnosing Selective Antibody Deficiency (SAD)

An evaluation typically includes measurement of total IgG, IgG subclasses and antibody titers to specific bacteria such as tetanus, diphtheria, and/or Streptococcus pneumoniae. When the total IgG or subclasses are low, a more profound immunodeficiency is usually present.

Treating Selective Antibody Deficiency (SAD)

Patients with SAD who frequently suffer recurrent or chronic infections of the ears, sinuses, bronchi and lungs require antibiotics. Immune globulin replacement therapy is needed for patients who fail to make antibodies against proteins or polysaccharide antigens. Immune globulin therapy can be administered into the blood stream intravenously (IVIG) or under the skin subcutaneously (SCIG).

This content is not intended to substitute professional medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.


Contact Nufactor

At Nufactor, we are committed to providing our patients the education, support and resources necessary to complete your IVIG treatment successfully and with the desired outcomes. Please contact us with any further questions.