Diagnoses & Conditions

Churg Strauss Syndrome (CSS)

Understanding Churg Strauss Syndrome (CSS)

Churg Strauss Syndrome (CSS) is a disorder categorized by blood vessel inflammation which can restrict blood flow to vital organs and tissues, sometimes permanently damaging them.

Symptoms of Churg Strauss Syndrome (CSS)

Asthma is the most common sign of CSS. The disorder can also cause a variety of other problems, such as hay fever, rash, gastrointestinal bleeding, and pain and numbness in your hands and feet.

Diagnosis of Churg Strauss Syndrome (CSS)

CSS is generally considered to be present if a person has four of six criteria fulfilled:

  • Asthma
  • Higher than normal white blood cell count (eosinophils/eosinophilia).
  • Mononeuropathy or Polyneuropathy (damage to one or more nerve groups).
  • Sinus problems.
  • White blood cells present outside blood vessels (extravascular eosinophils).

Blood tests, imaging test and a biopsy of affected tissue are also typically performed to help determine the criteria are met.

Treatment of Churg Strauss Syndrome (CSS)

Medications used to treat Churg Strauss Syndrome (CSS) include:

  • Immune globulin. Given as a monthly infusion into the blood stream intravenously (IVIG), it is generally given to people who have not responded to other treatments.
  • Corticosteroids. Prednisone is the most commonly prescribed drug for CSS. Your doctor may prescribe a high dose of corticosteroids or a boost in your current dose of corticosteroids to get your symptoms under control as soon as possible.
  • Other immunosuppressive drugs. For people with mild symptoms, a corticosteroid alone may be enough. Other people may require another immunosuppressive drug, such as cyclophosphamide, azathioprine (e.g., Imuran®) or methotrexate, to reduce the body's immune reaction still further.
  • Biologic medications. Drugs such as rituximab (e.g., Rituxan®) that alter the immune system's response seem to improve symptoms and decrease the number of eosinophils.

This content is not intended to substitute professional medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Contact Nufactor

At Nufactor, we are committed to providing our patients the education, support and resources necessary to complete your IVIG treatment successfully and with the desired outcomes. Please contact us with any further questions.