Diagnoses & Conditions

Lambert-Eaton Myasthenic Syndrome (LEMS)

Understanding Lambert-Eaton Myasthenic Syndrome (LEMS)

LEMS is a neuromuscular disorder (a condition that affects the nerves and muscles). LEMS occurs when antibodies cause the immune system to disrupt communication between nerves and muscles. LEMS disrupts the nerves ability to release a chemical (acetylcholine) which is necessary for the muscle to work properly.

Symptoms of Lambert-Eaton Myasthenic Syndrome (LEMS)

Symptoms of LEMS include slow progressive muscle weakness and fatigue. The patient may also experience frequent muscle aches and cramps. The progressive muscle weakness commonly involves muscles of the hips, legs and shoulders and can sometimes cause significant difficulty in completing everyday activities. Involuntary muscles can also be affected. Other symptoms include blurred vision, drooping eyelids, swallowing problems, dry mouth, constipation or erectile dysfunction.

Diagnosing Lambert-Eaton Myasthenic Syndrome (LEMS)

LEMS is diagnosed based on clinical symptoms, electromyographic (EMG) testing and testing for the presence of autoantibodies against voltage gated calcium channels.

LEMS can be categorized into two different classes

  • LEMS associated with small cell lung cancer (about 60% of LEMS patients).
  • LEMS without cancer association, also known as non-paraneoplastic Lambert-Eaton Myasthenic Syndrome.

Treating Lambert-Eaton Myasthenic Syndrome (LEMS)

Current treatment targets reduction of symptoms and can include:

  • Treatment of lung cancer for those patients with small cell lung cancer.
  • Medications to help nerve signals reach the muscles.
  • Medications targeted at reducing the number of antibodies, include immune globulin administered into the blood stream intravenously (IVIG), plasmapheresis, corticosteroids and immune suppressive medications such as azathioprine (e.g., Imuram®), mycophenolate (e.g., CellCept®), methotrexate and others, or monoclonal antibodies.

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This content is not intended to substitute professional medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.


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