Diagnoses & Conditions

Bone Marrow and Hematopoietic Stem Cell Transplant

Understanding Bone Marrow and Hematopoietic Stem Cell Transplant

BMT stands for bone marrow transplant, a procedure used to treat many different diseases that affect the bone marrow or blood cells. This type of treatment is considered extreme and is used when other therapies have been unsuccessful in achieving remission.

HSCT stands for hematopoietic stem cell transplant, which is similar to bone marrow transplant, but uses more mature cells that originate in the bone marrow but are usually collected from the peripheral blood. These cells are called stem cells. Today, most patients are treated with an HSCT instead of a BMT.

Types of Bone Marrow and Hematopoietic Stem Cell Transplant

There are two types of blood transplants used for BMT and HSCT. Allogeneic transplant is the type that uses donor cells. This entails wiping out the recipient’s cell production in their bone marrow and replacing it with donor cells.

Autologous transplant refers to using the patient’s own blood cells; this can be done when a patient may not have bone marrow involvement, but may need high doses of chemotherapy that can affect the production of stem cells.

Why BMT or HSCT is Used for Therapy

With a disease that affects the bone marrow and blood cell line, sometimes “replacing” the cells is the only option to promote patient survival and remission of an illness. By replacing the cells, the bone marrow is reprogrammed to make new cells from the transplanted cells. Some diseases treated with a BMT or HSCT include types of leukemia and lymphoma.

Immune globulin therapy administered into the blood stream intravenously (IVIG) is used to help prevent infections and to help strengthen and protect the immune system

When patients’ immune systems are “wiped out” from therapy or because disease has affected their bone marrow cells extensively, it is important to help strengthen their compromised immune systems that are not functioning to full capability. IVIG contains immune globulin type G (IgG), an infection-fighting antibody, and is often given when levels are low, usually while patients are waiting for the bone marrow to function and produce IgG. Patients may continue to have chronically low IgG levels several months after transplantation due to the prolonged period needed for full recovery. During this time, providing therapeutic levels of immune globulin may help prevent serious, life-threatening complications while undergoing successful transplantation.



This content is not intended to substitute professional medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Contact Nufactor

At Nufactor, we are committed to providing our patients the education, support and resources necessary to complete your IVIG treatment successfully and with the desired outcomes. Please contact us with any further questions.