Disease Treatments

Factor Deficiency

Factor X Deficiency

Understanding Factor X Deficiency

Inherited factor X deficiency is a rare bleeding disorder. It varies in severity among those who are affected. Acquired factor X deficiency is more common and may be due to a deficiency in vitamin K, use of certain anticoagulant medications (warfarin/Coumadin) or may be due to another illness such as severe liver disease or amyloidosis.

Symptoms of Factor X Deficiency

Symptoms of mild Factor X Deficiency include nosebleeds, easy bruising, bleeding under the skin, bleeding of the gums, blood in the urine (hematuria) and prolonged or excessive bleeding following surgery or trauma. Women who have a Factor X deficiency can have heavy or prolonged menstrual bleeding or excessive bleeding during childbirth. Symptoms for patients with severe Factor X deficiency include excessive umbilical cord bleeding, prolonged bleeding after circumcision, joint bleeds, intramuscular bleeds, and a high risk of intracranial hemorrhage in the first weeks of life.

Diagnosing Factor X Deficiency

Diagnosis is confirmed by a blood test called a factor X assay. Family history is important in the diagnosis of hereditary Factor X Deficiency. Other tests will be completed to measure the time it takes for blood to clot and include, prothrombin time (PT) test, partial thromboplastin time (PTT) or activated partial thromboplastin time (APTT) and thrombin time.

Treating Factor X Deficiency

Coagadex®, a coagulation Factor X (Human) product, manufactured by BioProdcuts (BPL) is prescribed for the treatment of inherited Factor X deficiency. Coagadex®, a plasma derived concentrate, is indicated for individuals (aged 12 and older) with hereditary Factor X deficiency for on-demand treatment and control of bleeding episodes, and for the perioperative management of bleeding in patients with mild hereditary Factor X deficiency. Treatment for patients with acquired factor X deficiency varies based on the cause or underlying condition.


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This content is not intended to substitute professional medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.